Neuregulin-1 is essential for nerve plexus formation during cardiac maturation

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Neuregulin‐1 is essential for nerve plexus formation during cardiac maturation

The Neuregulin-1 (Nrg1)/ErbB pathway plays multiple, critical roles in early cardiac and nervous system development and has been implicated in both heart and nerve repair processes. However, the early embryonic lethality of mouse Nrg1 mutants precludes an analysis of Nrg1's function in later cardiac development and homeostasis. In this study, we generated a novel nrg1 null allele targeting all ...

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ژورنال

عنوان ژورنال: Journal of Cellular and Molecular Medicine

سال: 2017

ISSN: 1582-1838

DOI: 10.1111/jcmm.13408